7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine → HCID 21241318, 화합물
반응식
[CH3:1][O-:2].[Na+].Cl[C:5]1[N:10]2[N:11]=[CH:12][N:13]=[C:9]2[N:8]=[C:7]([CH3:14])[CH:6]=1>CO>[CH3:1][O:2][C:5]1[N:10]2[N:11]=[CH:12][N:13]=[C:9]2[N:8]=[C:7]([CH3:14])[CH:6]=1참가 물질
4
실험 절차
A 28% methanol solution of sodium methoxide, 2.52 g, is diluted with 50 ml of dry methanol To this, 2.00 g of 7-chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine is added at room temperature and stirred for 30 minutes. The solvent is evaporated under reduced pressure and the residue is treated with water and extracted twice with dichloromethane. The combined extract is washed with saline and dried over anhydrous potassium carbonate. Evaporation of the solvent under reduced pressure gives 1.69 g of the desired compound as colorless crystals.
후처리
- additionis added at room temperature
- customThe solvent is evaporated under reduced pressure
- additionthe residue is treated with water
- extractionextracted twice with dichloromethane
- extractionThe combined extract
- washis washed with saline
- dry with materialdried over anhydrous potassium carbonate
- customEvaporation of the solvent under reduced pressure
출처 및 근거
- ORD 기록
- ord-c3d5bfc9aadd4fd0812780a285db81e8
- 출처 데이터셋
- uspto-grants-1989_05
- 특허 번호
- US04826834
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