Sulfuric Acid → 3-Bromo-2,4,5-trifluorobenzoic acid

HRID 1761647노트

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HRID 1761647 반응식
[Br:1][C:2]1[C:3]([F:13])=[C:4]([CH:8]=[C:9]([F:12])[C:10]=1[F:11])[C:5](N)=[O:6].S(=O)(=O)(O)[OH:15]>>[Br:1][C:2]1[C:3]([F:13])=[C:4]([CH:8]=[C:9]([F:12])[C:10]=1[F:11])[C:5]([OH:15])=[O:6]

참가 물질

3

반응물 2

HCID 1118Sulfuric AcidHCID 137488013-Bromo-2,4,5-trifluorobenzamide

생성물 1

HCID 27832463-Bromo-2,4,5-trifluorobenzoic acid

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온도
100 °C

실험 절차

A mixture of 3-bromo-2,4,5-trifluorobenzamide (8.7 g) and 18N-sulfuric acid (50 ml) was stirred at 100° C. for 4 hours, and then poured into ice water (200 ml). The resulting precipitate was collected by filtration and recrystallized from dichloro-methane-n-hexane to give the title compound (6.9 g), mp 125°-127° C.

후처리

  1. filtrationThe resulting precipitate was collected by filtration
  2. customrecrystallized from dichloro-methane-n-hexane

출처 및 근거

ORD 기록
ord-1740de5887144befa7cbdfabb2cab21c
출처 데이터셋
uspto-grants-1989_05
특허 번호
US04826982

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