Thionyl Chloride → 3-Bromo-2,4,5-trifluorobenzoyl chloride

HRID 1761648노트

반응식

HRID 1761648 반응식
[Br:1][C:2]1[C:3]([F:13])=[C:4]([CH:8]=[C:9]([F:12])[C:10]=1[F:11])[C:5](O)=[O:6].S(Cl)([Cl:16])=O>>[Br:1][C:2]1[C:3]([F:13])=[C:4]([CH:8]=[C:9]([F:12])[C:10]=1[F:11])[C:5]([Cl:16])=[O:6]

참가 물질

3

반응물 2

HCID 24386Thionyl ChlorideHCID 27832463-Bromo-2,4,5-trifluorobenzoic acid

생성물 1

HCID 137488023-Bromo-2,4,5-trifluorobenzoyl chloride

실험 절차

A solution of the 3-bromo-2,4,5-trifluorobenzoic acid (2.5 g) in thionyl chloride (10 ml) was refluxed for 2.5 hours, and then concentrated. The resulting residue was purified by distillation through Widmer fractionating column to give the title compound (2.3 g), bp 98°-102° C./18 mmHg.

후처리

  1. concentrationconcentrated
  2. distillationThe resulting residue was purified by distillation through Widmer fractionating column

출처 및 근거

ORD 기록
ord-e7c2bcbdd9f2453ebd6e159b46ed4b38
출처 데이터셋
uspto-grants-1989_05
특허 번호
US04826982

반응 노트

불러오는 중…