Ammonia → HCID 10997097, 화합물

반응식

[CH2:1]([N:4]([C:10]([O:12]C)=O)[CH2:5][C:6](OC)=[O:7])[C:2]#[CH:3].[NH3:14]>>[CH2:1]([N:4]1[CH2:5][C:6](=[O:7])[NH:14][C:10]1=[O:12])[C:2]#[CH:3]

참가 물질

반응물 2

HCID 222Ammonia

HCID 14580243HCID 14580243, 화합물

생성물 1

HCID 10997097HCID 10997097, 화합물

실험 절차

3.0 g of methyl N-propargyl-N-methoxycarbonylglycinate were dissolved in 40 ml of 28% aqueous ammonia. Then the mixture was maintained under the pressure of 10-13 kg/cm2 at 100°-110° C. for an hour. Then the solvent was evaporated off from the reaction mixture. The resulting mixture was subjected to a column chromatography on silica gel (5:1 ethyl acetate:methanol as eluent) to obtain 0.65 g of 1-propargyl-2,4-dioxoimidazolidine.

후처리

temperatureThen the mixture was maintained under the pressure of 10-13 kg/cm2 at 100°-110° C. for an hour
customThen the solvent was evaporated off from the reaction mixture

출처 및 근거

ORD 기록: ord-4f522af51f2d43db858a99d16f8429f9
출처 데이터셋: uspto-grants-1989_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04827020

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