2-Phenylbenzofuran-7-carboxylic acid → 2-Cyclohexylbenzofuran-7-carboxylic acid

HRID 1761906

반응식

HRID 1761906 반응식
[C:1]1([C:7]2[O:8][C:9]3[C:15]([C:16]([OH:18])=[O:17])=[CH:14][CH:13]=[CH:12][C:10]=3[CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>CO.O1CCCC1.[Pt]=O>[CH:1]1([C:7]2[O:8][C:9]3[C:15]([C:16]([OH:18])=[O:17])=[CH:14][CH:13]=[CH:12][C:10]=3[CH:11]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

참가 물질

5

반응물 1

HCID 142297062-Phenylbenzofuran-7-carboxylic acid

생성물 1

HCID 142297092-Cyclohexylbenzofuran-7-carboxylic acid수율 60.1%

시약·촉매·용매 3

HCID 82844Platinum oxide (PtO)촉매HCID 887Methanol용매HCID 8028Tetrahydrofuran용매

실험 절차

2.5 g of 2-phenylbenzofuran-7-carboxylic acid is dissolved in a mixture of 80 ml of methanol and 16 ml of tetrahydrofuran and 0.5 g of platinum oxide is added to the solution. The mixture is subjected to catalytic hydrogenation under atmospheric pressure. The reaction mixture is filtered and the filtrate is evaporated to remove solvent. The residue is purified by silica gel column chromatography (solvent; chloroform:methanol=20:1) to give 1.54 g of 2-cyclohexylbenzofuran-7-carboxylic acid as colorless oil.

후처리

  1. additionis added to the solution
  2. filtrationThe reaction mixture is filtered
  3. customthe filtrate is evaporated
  4. customto remove solvent
  5. customThe residue is purified by silica gel column chromatography (solvent; chloroform:methanol=20:1)

출처 및 근거

ORD 기록
ord-6e53bd05d1db455ca47f8363c774f39f
출처 데이터셋
uspto-grants-1989_05
특허 번호
US04829067

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