Tetrahydrofuran → Methyl 2-(4-nitrophenyl)benzofuran-7-carboxylate

HRID 1761908노트

반응식

HRID 1761908 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[O:11][C:12]3[C:18]([C:19]([OH:21])=[O:20])=[CH:17][CH:16]=[CH:15][C:13]=3[CH:14]=2)=[CH:6][CH:5]=1)([O-:3])=[O:2].O1CCC[CH2:23]1>>[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[O:11][C:12]3[C:18]([C:19]([O:21][CH3:23])=[O:20])=[CH:17][CH:16]=[CH:15][C:13]=3[CH:14]=2)=[CH:6][CH:5]=1)([O-:3])=[O:2]

참가 물질

3

반응물 2

HCID 8028TetrahydrofuranHCID 142297282-(4-Nitrophenyl)benzofuran-7-carboxylic acid

생성물 1

HCID 14229713Methyl 2-(4-nitrophenyl)benzofuran-7-carboxylate

실험 절차

A diazomethane-ether solution (prepared from 5.0 g of nitrosomethylurea) is added to a solution of 6.0 g of 2-(4-nitrophenyl)benzofuran-7-carboxylic acid in 60 ml of tetrahydrofuran and the mixture is stirred at room temperature for 1 hour. The reaction mixture is evaporated to remove solvent and the residue is dissolved in ethyl acetate. The solution is washed with water, dried and evaporated to remove solvent. The residue is washed with ethyl acetate and dried to give 3.82 g of methyl 2-(4-nitrophenyl)benzofuran-7-carboxylate as pale brown powder.

후처리

  1. customThe reaction mixture is evaporated
  2. customto remove solvent
  3. dissolutionthe residue is dissolved in ethyl acetate
  4. washThe solution is washed with water
  5. customdried
  6. customevaporated
  7. customto remove solvent
  8. washThe residue is washed with ethyl acetate
  9. customdried

출처 및 근거

ORD 기록
ord-0897e720d4e74ffa9f9a8c4b94f8a771
출처 데이터셋
uspto-grants-1989_05
특허 번호
US04829067

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