1,1'-Carbonyldiimidazole → 2-(t-Butylamino)ethyl 2-phenylbenzofuran-7-carboxylate

HRID 1761915

반응식

HRID 1761915 반응식
[C:1]1([C:7]2[O:8][C:9]3[C:15]([C:16]([OH:18])=[O:17])=[CH:14][CH:13]=[CH:12][C:10]=3[CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(N1C=CN=C1)(N1C=CN=C1)=O.[C:31]([NH:35][CH2:36][CH2:37]O)([CH3:34])([CH3:33])[CH3:32]>O1CCCC1>[C:1]1([C:7]2[O:8][C:9]3[C:15]([C:16]([O:18][CH2:37][CH2:36][NH:35][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:17])=[CH:14][CH:13]=[CH:12][C:10]=3[CH:11]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

5

반응물 3

HCID 682631,1'-CarbonyldiimidazoleHCID 783612-(tert-Butylamino)ethanolHCID 142297062-Phenylbenzofuran-7-carboxylic acid

생성물 1

HCID 142298072-(t-Butylamino)ethyl 2-phenylbenzofuran-7-carboxylate수율 84.9%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

1.43 g of 2-phenylbenzofuran-7-carboxylic acid are dissolved in 10 ml of tetrahydrofuran, and 1.08 g of carbonyldiimidazole are added to the solution. The mixture is stirred at room temperature for 2 hours and a solution of 0.76 g of 2-(t-butylamino)ethanol in 4 ml of tetrahydrofuran is added thereto. The mixture is stirred at room temperature for 15 hours and evaporated to remove solvent. Water is added to the residue and the aqueous mixture is extracted with ethyl acetate. The extract is washed with water, dried, and evaporated to remove solvent to give 1.72 g of 2-(t-butylamino)ethyl 2-phenylbenzofuran-7-carboxylate as pale yellow oil.

후처리

  1. stirringThe mixture is stirred at room temperature for 15 hours
  2. customevaporated
  3. customto remove solvent
  4. additionWater is added to the residue
  5. extractionthe aqueous mixture is extracted with ethyl acetate
  6. washThe extract is washed with water
  7. customdried
  8. customevaporated
  9. customto remove solvent

출처 및 근거

ORD 기록
ord-1e2808da575d4693abce88953851768c
출처 데이터셋
uspto-grants-1989_05
특허 번호
US04829067

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