HCID 14516783, 화합물 → HCID 14516793, 화합물

HRID 1762039노트

반응식

HRID 1762039 반응식
[CH2:1]([O:3][C:4]([C:6]1[N:7]=[CH:8][N:9]([C:15]2[S:16][CH:17]=[N:18][N:19]=2)[C:10]=1[S:11]([NH2:14])(=[O:13])=[O:12])=[O:5])[CH3:2].[CH3:20][O:21][C:22]1[CH:27]=[C:26]([O:28][CH3:29])[N:25]=[C:24]([N:30](C2C=CC=CC=2)[C:31](=O)[O-:32])[N:23]=1>C(#N)C>[CH3:29][O:28][C:26]1[CH:27]=[C:22]([O:21][CH3:20])[N:23]=[C:24]([NH:30][C:31]([NH:14][S:11]([C:10]2[N:9]([C:15]3[S:16][CH:17]=[N:18][N:19]=3)[CH:8]=[N:7][C:6]=2[C:4]([O:3][CH2:1][CH3:2])=[O:5])(=[O:13])=[O:12])=[O:32])[N:25]=1

참가 물질

4

반응물 2

HCID 14516783HCID 14516783, 화합물HCID 22104197HCID 22104197, 화합물

생성물 1

HCID 14516793HCID 14516793, 화합물수율 62.6%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

0.23 g of 1,8-diazobicyclo(5,4,0)-7-undecene was added dropwise to a mixture of 0.45 g of 4-ethoxycarbonyl-1-(1,3,4-thiadiazol-2-yl)imidazole-5-sulfonamide, 0.41 g of N-(4,6-dimethoxypyrimidine-2-yl)phenylcarbamate and 5 ml of acetonitrile. After stirring the reaction mixture at room temperature for 20 minutes, 20 ml of ice water was added thereto and the mixture was filtered. The filtrate was made acidic with use of conc. hydrochloric acid, and resulting precipitated crystals were collected by filtration, washed with water and ethyl ether, and dried to obtain 0.45 g of the title compound. m.p.: 169° to 171° C.

후처리

  1. filtrationthe mixture was filtered
  2. customresulting
  3. customprecipitated crystals
  4. filtrationwere collected by filtration
  5. washwashed with water and ethyl ether
  6. customdried

출처 및 근거

ORD 기록
ord-9c8b4f252f3041eba5b5f04d0673f3a6
출처 데이터셋
uspto-grants-1989_05
특허 번호
US04830660

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