Oxalyl chloride → 3-Oxazolidineacetyl chloride, 2-oxo-4,5-diphenyl-, (4S,5R)-

HRID 1762168노트

반응식

HRID 1762168 반응식
[C:1]1([C@H:7]2[C@@H:11]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[O:10][C:9](=[O:18])[N:8]2[CH2:19][C:20]([OH:22])=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(Cl)(=O)C([Cl:26])=O>C1C=CC=CC=1>[C:1]1([C@H:7]2[C@@H:11]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[O:10][C:9](=[O:18])[N:8]2[CH2:19][C:20]([Cl:26])=[O:22])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

4

반응물 2

HCID 65578Oxalyl chlorideHCID 58430307[(4S,5R)-2-Oxo-4,5-diphenyl-1,3-oxazolidin-3-yl]acetic acid

생성물 1

HCID 109359773-Oxazolidineacetyl chloride, 2-oxo-4,5-diphenyl-, (4S,5R)-수율 100%

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

A suspension composed of (4,5-cis-diphenyl-2-oxo-3-oxazolidinyl)acetic acid (29.1 g, 97.9 mmol), oxalyl chloride (18.6 g, 147 mmol) and benzene (120 ml) was refluxed for 2 hours. When the suspension became homogeneous, the solvent was distilled off. By the above procedure there was obtained the title compound (30.9 g) as light brown oil.

후처리

  1. temperaturewas refluxed for 2 hours
  2. distillationthe solvent was distilled off

출처 및 근거

ORD 기록
ord-aa46dd4435d04b2cb110922d77ee3904
출처 데이터셋
uspto-grants-1989_05
특허 번호
US04831026

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