Water → 6-Methyl-2-methylaminobenzyl alcohol
반응식
[CH:1]([NH:3][C:4]1[CH:11]=[CH:10][CH:9]=[C:8]([CH3:12])[C:5]=1[CH2:6][OH:7])=O.[H-].[Al+3].[Li+].[H-].[H-].[H-].O>O1CCCC1>[CH3:12][C:8]1[C:5]([CH2:6][OH:7])=[C:4]([NH:3][CH3:1])[CH:11]=[CH:10][CH:9]=1참가 물질
5
실험 절차
A solution of 2-formamido-6-methylbenzyl alcohol (1.9 g) in tetrahydrofuran (26 ml) was added dropwise to a suspension of lithium aluminum hydride (0.873 g) in tetrahydrofuran (17 ml) at room temperature over a period of 10 minutes. After being refluxed for 4.5 hours, the excess reagent was decomposed with a small amount of water and the resulting precipitates were filtered off by suction. The filtrate was evaporated in vacuo and the residue was recrystallized from carbon tetrachloride to give 6-methyl-2-methylaminobenzyl alcohol (0.86 g).
후처리
- temperatureAfter being refluxed for 4.5 hours
- customthe resulting precipitates
- filtrationwere filtered off by suction
- customThe filtrate was evaporated in vacuo
- customthe residue was recrystallized from carbon tetrachloride
출처 및 근거
- ORD 기록
- ord-d1b51f6357394f49aaea3d7e4e62f200
- 출처 데이터셋
- uspto-grants-1989_05
- 특허 번호
- US04831041
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