Ethyl 2-oxocyclohexanecarboxylate → HCID 14053650, 화합물

반응식

[F:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[NH:11][NH2:12].CC[O:15][C:16]([CH:18]1[C:23](=O)[CH2:22][CH2:21][CH2:20][CH2:19]1)=O>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[N:11]1[C:16](=[O:15])[C:18]2[CH2:23][CH2:22][CH2:21][CH2:20][C:19]=2[NH:12]1

참가 물질

반응물 2

HCID 95543Ethyl 2-oxocyclohexanecarboxylate

HCID 13849098(2-Fluoro-5-nitrophenyl)hydrazine

생성물 1

HCID 14053650HCID 14053650, 화합물

실험 절차

A solution of 2-fluoro-5-nitrophenylhydrazine (53.95 g) in ethyl 2-cyclohexanonecarboxylate (53.65 g) was heated under reflux for 4 hours. After cooling, the reaction mixture was poured into ice-water. The precipitated crystals were collected by filtration, washed with water and hexane and dried to obtain 2-(2-fluoro-5-nitrophenyl)1,2,4,5,6,7-hexahydro-3H-indazol-3-one. m.p., 220.0° C.

후처리

temperatureunder reflux for 4 hours
temperatureAfter cooling
filtrationThe precipitated crystals were collected by filtration
washwashed with water and hexane
customdried

출처 및 근거

ORD 기록: ord-af1bd6f0f66348779576d0791d3e0bd2
출처 데이터셋: uspto-grants-1989_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04831149

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