N-(Hydroxymethyl)-3,4,5,6-tetrahydrophthalimide → 2,2-Dimethyl-3-(3-cyclopropylmethoxy-3-oxo-1-propenyl) cyclopropane-carboxylic acid

HRID 1762620

반응식

HRID 1762620 반응식
[CH3:1][C:2]1([CH3:17])[CH:4]([CH:5]=[CH:6][C:7]([O:9][CH2:10][CH:11]2[CH2:13][CH2:12]2)=[O:8])[CH:3]1[C:14]([OH:16])=[O:15].O=C1C2CCCCC=2C(=O)N1CO>>[CH3:1][C:2]1([CH3:17])[CH:4]([CH:5]=[CH:6][C:7]([O:9][CH2:10][CH:11]2[CH2:13][CH2:12]2)=[O:8])[CH:3]1[C:14]([OH:16])=[O:15].[CH3:17][C:2]1([CH3:1])[CH:4]([CH:5]=[CH:6][C:7]([O:9][CH2:10][CH2:11][CH3:12])=[O:8])[CH:3]1[C:14]([O-:16])=[O:15]

참가 물질

4

반응물 2

HCID 78597N-(Hydroxymethyl)-3,4,5,6-tetrahydrophthalimideHCID 539155962,2-Dimethyl-3-(3-cyclopropylmethoxy-3-oxo-1-propenyl) cyclopropane-carboxylic acid

생성물 2

HCID 539155962,2-Dimethyl-3-(3-cyclopropylmethoxy-3-oxo-1-propenyl) cyclopropane-carboxylic acidHCID 736552732,2-Dimethyl-3-(3-propoxy-3-oxo-1-propenyl)-cyclopropane-carboxylate

실험 절차

Using the procedure of Example 9, (1R, cis, ΔZ) 2,2-dimethyl-3-(3-n-propoxy-3-oxo-1-propenyl)-cyclopropane-carboxylic acid and (1,3,4,5,6,7-hexahydro-1,3-dioxo-2H-isoindol-2-yl)-methanol were reacted to obtain (1,3,4,5,6,7-hexahydro-1,3-dioxo-2H-isoindol-2-yl)-methyl (1R, cis ΔZ) 2,2-dimethyl-3-(3-n-propoxy-3-oxo-1-propenyl)-cyclopropane-carboxylate with a melting point of 76° C. and a specific rotation of [α]D20 =-15° (c=0.15%) in carbon tetrachloride).

후처리

  1. customwere reacted

출처 및 근거

ORD 기록
ord-194679468cd34c56b5f6fbe4c06899ef
출처 데이터셋
uspto-grants-1989_05
특허 번호
US04833163

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