Chlorosulfonic acid → 4-(1-Acetylpiperidin-4-yl)benzenesulphonyl chloride

HRID 1762837노트

반응식

HRID 1762837 반응식
[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[Cl:16][S:17](O)(=[O:19])=[O:18]>>[C:1]([N:4]1[CH2:5][CH2:6][CH:7]([C:10]2[CH:15]=[CH:14][C:13]([S:17]([Cl:16])(=[O:19])=[O:18])=[CH:12][CH:11]=2)[CH2:8][CH2:9]1)(=[O:3])[CH3:2]

참가 물질

3

반응물 2

HCID 24638Chlorosulfonic acidHCID 11608128HCID 11608128, 화합물

생성물 1

HCID 200398204-(1-Acetylpiperidin-4-yl)benzenesulphonyl chloride

실험 절차

1-Acetyl-4-phenylpiperidine, [Chem. Abs., 75, 5728b (1971] (16.30 g) was added portionwise over 1 hour to stirred chlorosulphonic acid (53.3 ml) at 0°. The solution was stirred at 0° for 1 hour, then at room temperature for 2 hours, and then finally poured cautiously onto an excess of ice. When the ice had melted the mixture was extracted several times with dichloromethane. The combined organic extracts were washed with water, dried (Na2SO4) and evaporated to give the title compound, (23.0 g), m.p. 133°-134°, used directly in the next step.

후처리

  1. waitat room temperature for 2 hours
  2. additionfinally poured cautiously onto an excess of ice
  3. extractionwas extracted several times with dichloromethane
  4. washThe combined organic extracts were washed with water
  5. dry with materialdried (Na2SO4)
  6. customevaporated

출처 및 근거

ORD 기록
ord-7758a8711e374a31a578e2d63a02b74d
출처 데이터셋
uspto-grants-1989_05
특허 번호
US04835165

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