HCID 13935130, 화합물 → 104628-28-6

HRID 1763040노트

반응식

HRID 1763040 반응식
[CH3:1][O:2][C:3]1[CH:25]=[CH:24][C:6]([CH2:7][NH:8][C:9]2[C:10]3[C:15]([N:16]=[C:17]4[C:22]=2[C:21](=[O:23])[CH2:20][CH2:19][CH2:18]4)=[CH:14][CH:13]=[CH:12][CH:11]=3)=[CH:5][CH:4]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>C1COCC1>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:7][NH:8][C:9]2[C:10]3[C:15]([N:16]=[C:17]4[C:22]=2[CH:21]([OH:23])[CH2:20][CH2:19][CH2:18]4)=[CH:14][CH:13]=[CH:12][CH:11]=3)=[CH:24][CH:25]=1

참가 물질

4

반응물 2

HCID 13935130HCID 13935130, 화합물HCID 21226445Aluminium lithium hydride

생성물 1

HCID 3025618104628-28-6

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

3,4-Dihydro-9-(4-methoxybenzylamino)acridin-1(2H)-one (4.25 g) was dissolved in 75 ml of dry THF and chilled with ice-water. 1M lithium aluminum hydride in THF (7.0 ml) was then added dropwise. After 15 minutes the reaction was quenched by the sequential dropwise addition of 0.4 ml of water, 0.4 ml of 15sodium hydride and 1.2 ml of water. The inorganic salts were filtered off, the solvents were evaporated, and the residue recrystallized from dichloromrthane-ether to give 3.0 g of analytically pure product, mp 163°-165° C.

후처리

  1. customAfter 15 minutes the reaction was quenched by the sequential dropwise addition of 0.4 ml of water, 0.4 ml of 15sodium hydride and 1.2 ml of water
  2. filtrationThe inorganic salts were filtered off
  3. customthe solvents were evaporated
  4. customthe residue recrystallized from dichloromrthane-ether
  5. customto give 3.0 g of analytically pure product, mp 163°-165° C.

출처 및 근거

ORD 기록
ord-e0a7289b379d407685e78dd712555b5d
출처 데이터셋
uspto-grants-1989_05
특허 번호
US04835275

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