Triethylamine → HCID 13233034, 화합물

HRID 1763187노트

반응식

HRID 1763187 반응식
Cl.[C:2]([S:6][CH2:7][NH:8][CH3:9])([CH3:5])([CH3:4])[CH3:3].[F:10][C:11]([F:22])([F:21])[C:12]1[CH:13]=[C:14]([N:18]=[C:19]=[O:20])[CH:15]=[CH:16][CH:17]=1.C(N(CC)CC)C>C(#N)C>[CH3:9][N:8]([CH2:7][S:6][C:2]([CH3:5])([CH3:4])[CH3:3])[C:19]([NH:18][C:14]1[CH:15]=[CH:16][CH:17]=[C:12]([C:11]([F:10])([F:21])[F:22])[CH:13]=1)=[O:20]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 94833-(Trifluoromethyl)phenyl isocyanateHCID 20309108N-(tert.-butylthiomethyl)-N-methyl amine hydrochloride

생성물 1

HCID 13233034HCID 13233034, 화합물

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

Two grams of the product of Example I (0.0118 mole), 2.2 g. (0.0118 mole) of 3-trifluoromethylphenylisocyanate, and 100 ml. of acetonitrile are combined in a 250 ml. Erlenmeyer flask. The mixture is magnetically stirred, and 1.9 g. (0.0118 mole) of triethylamine are then added. The resulting mixture is stirred at room temperature for one hour and then poured into 300 ml. of ice water. The crystalline product is collected by filtration and dried to yield 2.0 g. (53% of theory) of the title compound, mp = 96°-99° C. Structure is confirmed by IR and NMR.

후처리

  1. stirringThe resulting mixture is stirred at room temperature for one hour
  2. additionpoured into 300 ml
  3. filtrationThe crystalline product is collected by filtration
  4. customdried
  5. customto yield 2.0 g

출처 및 근거

ORD 기록
ord-a6aadf5ed0a140938581a74509fa2f68
출처 데이터셋
uspto-grants-1978_09
특허 번호
US04111682

반응 노트

불러오는 중…