2-Chlorothiazole → 1-[(Naphthalen-2-yl)methyl]-4-(1,3-thiazol-2-yl)piperazine

HRID 1763453

반응식

HRID 1763453 반응식
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][N:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1.Cl[C:19]1[S:20][CH:21]=[CH:22][N:23]=1>CN(C)C=O>[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][N:12]1[CH2:13][CH2:14][N:15]([C:19]2[S:20][CH:21]=[CH:22][N:23]=2)[CH2:16][CH2:17]1

참가 물질

4

반응물 2

HCID 764292-ChlorothiazoleHCID 9105371-(Naphthalen-2-ylmethyl)piperazine

생성물 1

HCID 203103421-[(Naphthalen-2-yl)methyl]-4-(1,3-thiazol-2-yl)piperazine수율 54.9%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

In a manner similar to that described above, but starting from 45.2 g (0.2 mole) of 1-(2-naphthylmethyl)-piperazine and 12 g (0.1 mole) of 2-chlorothiazole in 150 ml of dimethylformamide at 150° C., there were obtained 17 g of 1-(2-naphthylmethyl)-4-(2-thiazolyl)-piperazine as beige crystals melting at 83°-84° C.

출처 및 근거

ORD 기록
ord-3efcaee71f41492089ca12dedd5cc4cf
출처 데이터셋
uspto-grants-1978_09
특허 번호
US04112092

연결된 노트

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