Diethyl Oxalate → 1-Ethyl-2,3-piperazinedione

참여 물질

반응 단계

Into a mixture comprising 8 g of a diethyl ester of oxalic acid and 8 ml of ethanol was dropped at room temperature 4.4 g of N-ethyl ethylenediamine. The resulting mixture was allowed to react for 3 hours, an then heated to remove the ethanol. Subsequently, the residue was recrystallized from 10 ml of dioxane to obtain 5.4 g of 1-ethyl-2,3-dioxopiperazine, m.p. 124° C., yield 76.0%.

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