Triethylamine → 5-(4-Fluorobenzoyloxy)-3-methyl-4-phenyl-1-(alpha-methyl-3,4-dichlorobenzyl)-pyrazole

HRID 1763560노트

반응식

HRID 1763560 반응식
[CH3:1][C:2]1[NH:3][N:4]([CH:14]([CH3:23])[C:15]2[CH:20]=[CH:19][C:18]([Cl:21])=[C:17]([Cl:22])[CH:16]=2)[C:5](=[O:13])[C:6]=1[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.C(N(CC)CC)C.[F:31][C:32]1[CH:40]=[CH:39][C:35]([C:36](Cl)=[O:37])=[CH:34][CH:33]=1>O1CCOCC1>[F:31][C:32]1[CH:40]=[CH:39][C:35]([C:36]([O:13][C:5]2[N:4]([CH:14]([CH3:23])[C:15]3[CH:20]=[CH:19][C:18]([Cl:21])=[C:17]([Cl:22])[CH:16]=3)[N:3]=[C:2]([CH3:1])[C:6]=2[C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[O:37])=[CH:34][CH:33]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 678794-Fluorobenzoyl chlorideHCID 203358943-Methyl-4-phenyl-1-(alpha-methyl-3,4-dichlorobenzyl)-5-pyrazolone

생성물 1

HCID 203358595-(4-Fluorobenzoyloxy)-3-methyl-4-phenyl-1-(alpha-methyl-3,4-dichlorobenzyl)-pyrazole

시약·촉매·용매 1

HCID 312751,4-Dioxane용매2회

실험 절차

0.1 mol (34.7 g) of 3-methyl-4-phenyl-1-(α-methyl-3,4-dichlorobenzyl)-5-pyrazolone was dissolved in 300 ml of absolute dioxane. After adding 15 ml of triethylamine, 0.11 mol (17 g) of p-fluorobenzoyl chloride in dioxane was added dropwise. After heating for several hours under reflux, the reaction batch was worked up as follows.

후처리

  1. additionwas added dropwise
  2. temperatureAfter heating for several hours
  3. temperatureunder reflux

출처 및 근거

ORD 기록
ord-dd297b95e2ab4610a6ffe85fbfa5bfdf
출처 데이터셋
uspto-grants-1978_09
특허 번호
US04112109

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