참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 4-Pyridinemethanamine | HCID 77317 | — |
| 반응물 | 3-Nitropyridine | HCID 137630 | — |
| 반응물 | (6-Methylpyridin-2-yl)methanamine | HCID 246721 | — |
| 반응물 | [4-(Trifluoromethyl)pyridin-2-yl]methanamine | HCID 3682810 | — |
| 반응물 | 5-(Aminomethyl)-2-methylpyridin-3-amine | HCID 15619187 | — |
| 반응물 | 4-Phenyl-2-pyridinemethanamine | HCID 19863500 | — |
| 반응물 | 2-(Aminomethyl)-3-diethylaminopyridine | HCID 20310446 | — |
| 반응물 | N-(2-(Aminomethyl)pyridin-4-yl)acetamide | HCID 20310472 | — |
| 반응물 | 2-(Aminomethyl)-4-methylthiopyridine | HCID 20310480 | — |
| 반응물 | 2-(5-Ethylpyridin-2-YL)ethanamine | HCID 20310482 | — |
| 반응물 | 2-(Aminomethyl)-3-ethylaminopyridine | HCID 20310488 | — |
| 반응물 | 2-(Aminomethyl)-4-benzylpyridine | HCID 20310503 | — |
| 반응물 | (3-Chloropyridin-2-yl)methanamine | HCID 21280361 | — |
| 반응물 | (4-Methoxypyridin-2-yl)methanamine | HCID 22292761 | — |
| 생성물 | 1-(3-Fluorophenyl)-3-(pyridin-4-ylmethyl)thiourea | HCID 797529 | — |
반응 단계
Similarly, following the above procedure but replacing the 4-aminomethylpyridine as used therein with an equal molar proportion of 2-aminomethyl-6-methylpyridine, 2-(2-aminoethyl)-5-ethylpyridine, 3-amino-5-(aminomethyl)-2-methylpyridine, 2-(aminomethyl)-3-chloropyridine, 2-(aminomethyl)-4-phenylpyridine, 2-(aminomethyl)-4-benzylpyridine, 2-(aminomethyl)-4-methoxypyridine, 2-(aminomethyl)-4-methylthiopyridine, 2-aminomethyl)-3-nitropyridine, 2-(aminomethyl)-3-ethylaminopyridine, 2-(aminomethyl)-3-diethylaminopyridine, 2-(aminomethyl)-4-acetylaminopyridine, and 2-(aminomethyl)-4-trifluoromethylpyridine, respectively, all of which may be prepared by reduction of the corresponding nitrile of formula (IVC) according to the method of Sculley, et al., supra., there is obtained
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04112100 |
|---|
| 출처 데이터셋 | uspto-grants-1978_09 |
|---|
| ORD ID | ord-3827ead1dea846eeb89074e908757f56 |
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| 출처 메모 | uspto-grants-1978_09 |
|---|
