Methanol → O-Methyl-D-tyrosine methyl ester HCl

HRID 1763743노트

반응식

HRID 1763743 반응식
Cl.[CH3:2][O:3][C:4]1[CH:15]=[CH:14][C:7]([CH2:8][C@H:9]([C:11]([OH:13])=[O:12])[NH2:10])=[CH:6][CH:5]=1.[CH3:16]O.S(Cl)([Cl:20])=O>N1C=CC=CC=1>[ClH:20].[CH3:16][O:12][C:11](=[O:13])[C@@H:9]([CH2:8][C:7]1[CH:6]=[CH:5][C:4]([O:3][CH3:2])=[CH:15][CH:14]=1)[NH2:10]

참가 물질

5

반응물 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 51358314O-Methyl-D-tyrosine--hydrogen chloride (1/1)

생성물 1

HCID 24938358O-Methyl-D-tyrosine methyl ester HCl

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

O-Methyl-D-tyrosine hydrochloride, 10.0 g., in 100 ml. of methanol is cooled in an ice bath and treated slowly with 3.4 ml. of thionyl chloride. The reaction is stirred for one hour with cooling and then overnight at room temperature. The solution is evaporated to dryness and the residue crystallized from methanol-ether to give 5.2 g. of the above named compound mp. 189°-190° C., [α]D23 -68° (c 1.04, pyridine).

후처리

  1. additiontreated slowly with 3.4 ml
  2. temperaturewith cooling
  3. customovernight
  4. customat room temperature
  5. customThe solution is evaporated to dryness
  6. customthe residue crystallized from methanol-ether
  7. customto give 5.2 g

출처 및 근거

ORD 기록
ord-28de2ce7fb2245979a99bb6c0a0a76e0
출처 데이터셋
uspto-grants-1978_09
특허 번호
US04111923

반응 노트

불러오는 중…