Ethanolamine → N-(2-hydroxyethyl)-2,4-dimethylbenzenesulfonamide

HRID 1763754노트

반응식

HRID 1763754 반응식
[CH2:1]([CH2:3][NH2:4])[OH:2].C(N(CC)CC)C.[CH3:12][C:13]1[CH:18]=[C:17]([CH3:19])[CH:16]=[CH:15][C:14]=1[S:20](Cl)(=[O:22])=[O:21]>O1CCCC1>[OH:2][CH2:1][CH2:3][NH:4][S:20]([C:14]1[CH:15]=[CH:16][C:17]([CH3:19])=[CH:18][C:13]=1[CH3:12])(=[O:22])=[O:21]

참가 물질

5

반응물 3

HCID 700EthanolamineHCID 8471TriethylamineHCID 69109Benzenesulfonyl chloride, 2,4-dimethyl-

생성물 1

HCID 15942937N-(2-hydroxyethyl)-2,4-dimethylbenzenesulfonamide

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

To 40 parts of tetrahydrofuran are added 1.5 parts of ethanolamine and 2.5 parts of triethylamine. Into this solution, 10 parts of tetrahydrofuran containing 5 parts of 2,4-dimethylbenzenesulfonyl chloride is dropped with stirring. After the dropping, the resultant mixture is stirred as it is for 30 minutes. Subsequently, the salt is removed by filtration, and the filtrate is freed from the solvent to form a solid. This solid is recrystallized from isopropyl ether to obtain 3.6 parts of N-2-hydroxyethyl-2,4-dimethylbenzenesulfonamide, m.p. 70°-72° C.

후처리

  1. customSubsequently, the salt is removed by filtration
  2. customto form a solid
  3. customThis solid is recrystallized from isopropyl ether

출처 및 근거

ORD 기록
ord-56e5dd4761ec402d917d14bccafa9628
출처 데이터셋
uspto-grants-1978_09
특허 번호
US04113463

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