Benzene → HCID 20307409, 화합물

HRID 1763777노트

반응식

HRID 1763777 반응식
[CH2:1]([NH:4][CH2:5][CH:6]([O:9][CH3:10])[O:7][CH3:8])[C:2]#[CH:3].C1C=CC=CC=1.C(=O)([O-])[O-].[Na+].[Na+].[Cl:23][CH2:24][C:25](Cl)=[O:26]>O>[CH2:1]([N:4]([CH2:5][CH:6]([O:9][CH3:10])[O:7][CH3:8])[C:25](=[O:26])[CH2:24][Cl:23])[C:2]#[CH:3]

참가 물질

6

반응물 4

HCID 241BenzeneHCID 6577Chloroacetyl chlorideHCID 10340Sodium CarbonateHCID 20307436N-(2,2-Dimethoxyethyl)prop-2-yn-1-amine

생성물 1

HCID 20307409HCID 20307409, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

N-Propargyl-N-(2,2-dimethoxyethyl)amine (9 grams), benzene (100 ml), water (100 ml) and sodium carbonate (8 grams) were charged into a glass reaction vessel equipped with a mechanical stirrer and thermometer. The reaction mixture was cooled to a temperature of 5° to 10° C. and chloroacetyl chloride (5 ml) was added dropwise with stirring. Stirring was then continued until the reaction mixture reached room temperature. After this time the organic phase was separated from the aqueous phase, was washed with water and was dried. The dried solution was then filtered and the filtrate stripped of solvent to yield the desired product N-propargyl-N-(2,2-dimethoxyethyl)-α-chloroacetamide as the residue.

후처리

  1. customequipped with a mechanical stirrer
  2. additionwas added dropwise
  3. stirringStirring
  4. customreached room temperature
  5. customAfter this time the organic phase was separated from the aqueous phase
  6. washwas washed with water
  7. customwas dried
  8. filtrationThe dried solution was then filtered

출처 및 근거

ORD 기록
ord-8ff2749da5ad433d953f2855b9bff8c0
출처 데이터셋
uspto-grants-1978_09
특허 번호
US04113464

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