2-Methylbenzenesulfonic acid → HCID 20307437, 화합물

HRID 1763778노트

반응식

HRID 1763778 반응식
[CH2:1]([N:4]([CH2:9][CH:10]([O:13][CH3:14])[O:11][CH3:12])[C:5](=[O:8])[CH2:6][Cl:7])[C:2]#[CH:3].C1(C)C(S(O)(=O)=O)=CC=CC=1.C(=O)([O-])[O-].[Na+].[Na+]>C(O)C>[CH2:1]([N:4]([CH2:9][CH:10]1[O:11][CH2:12][CH2:14][O:13]1)[C:5](=[O:8])[CH2:6][Cl:7])[C:2]#[CH:3]

참가 물질

5

반응물 3

HCID 69252-Methylbenzenesulfonic acidHCID 10340Sodium CarbonateHCID 20307409HCID 20307409, 화합물

생성물 1

HCID 20307437HCID 20307437, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

N-Propargyl-N-(2,2-dimethoxyethyl)-α-chloroacetamide (8.5 grams), ethandiol-1,2 (2.16 ml) and trace amounts of toluenesulfonic acid were charged into a glass reaction vessel equipped with a mechanical stirrer, thermometer and reflux condenser. The reaction mixture was heated at reflux until no more ethanol was given off. After this time sodium carbonate (1 gram) was added to the mixture with stirring and the resulting mixture was distilled to yield the desired product N-propargyl-N-(1,3-dioxolan-2-ylmethyl)-α-chloroacetamide having a boiling point of 160° to 165° C. at 1 mm of Hg pressure.

후처리

  1. additionwere charged into a glass reaction vessel
  2. customequipped with a mechanical stirrer
  3. temperaturethermometer and reflux condenser
  4. temperatureThe reaction mixture was heated
  5. distillationthe resulting mixture was distilled

출처 및 근거

ORD 기록
ord-9a5c7a12461a462ca56932389872f23b
출처 데이터셋
uspto-grants-1978_09
특허 번호
US04113464

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