6-Methyluracil → 5-Fluoro-6-methylpyrimidine-2,4-diol

HRID 1763947노트

반응식

HRID 1763947 반응식
[CH3:1][C:2]1[NH:7][C:6](=[O:8])[NH:5][C:4](=[O:9])[CH:3]=1.[F:10]F>O>[F:10][C:3]1[C:4](=[O:9])[NH:5][C:6](=[O:8])[NH:7][C:2]=1[CH3:1]

참가 물질

4

반응물 2

HCID 122836-MethyluracilHCID 24524Fluorine2회

생성물 1

HCID 2338935-Fluoro-6-methylpyrimidine-2,4-diol

시약·촉매·용매 1

HCID 962Water용매

실험 절차

The preceding example was substantially repeated but at a lower reaction temperature. A suspension of 6-methyl uracil (4.00 g) in water (30 ml) was maintained at 0°-10° C. and fluorinated with a stream of fluorine and nitrogen, present in equal volumes, until fluorine was detected at the reactor outlet. The reaction mixture was allowed to stand for two days at room temperature and 1.05 g of crystals were collected and found to have a different IR spectrum than the starting material. A DSC analysis showed 2 transitions at 313° C. and 318° C. followed by apparent decomposition. The structure of the product was identified as 5-fluoro-6-methyl uracil by NMR analysis.

후처리

  1. temperaturewas maintained at 0°-10° C.
  2. custom1.05 g of crystals were collected
  3. customat 313° C.
  4. custom318° C.

출처 및 근거

ORD 기록
ord-b41060b5f54b4cd594ddfc40259e85e8
출처 데이터셋
uspto-grants-1978_09
특허 번호
US04113949

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