1H-imidazole-2-carbaldehyde → HCID 23346561, 화합물

HRID 1764045노트

반응식

HRID 1764045 반응식
[CH3:1][CH:2]1[CH2:6][CH2:5][C:4]2([C:11]([CH3:13])([CH3:12])[CH2:10][CH2:9][CH2:8][C:7]2([CH3:15])[OH:14])[O:3]1.[CH:16](C1NC=CN=1)=[O:17]>>[CH:16]([O:14][C:7]1([CH3:15])[CH2:8][CH2:9][CH2:10][C:11]([CH3:13])([CH3:12])[C:4]21[O:3][CH:2]([CH3:1])[CH2:6][CH2:5]2)=[O:17]

참가 물질

3

반응물 2

HCID 249551H-imidazole-2-carbaldehydeHCID 654286-Hydroxydihydrotheaspirane

생성물 1

HCID 23346561HCID 23346561, 화합물

실험 절차

0.4 g (0.002 M) of 2,6,10,10-tetramethyl-1-oxa-spiro[4.5]decan-6-ol -- isomer A; see Example 1 -- were intimately mixed with 0.5 g (0.005 M) of freshly sublimated formylimidazole and then kept for 2 days at room temperature. The reaction mixture was then extracted with ether and the organic layer washed, dried, evaporated and finally subjected to a fractional distillation to give 0.3 g of a product having b.p. 70°-80°/0.5 Torr and containing 60% of the desired ester. An analytical sample was purified by vapour phase chromatography.

후처리

  1. extractionThe reaction mixture was then extracted with ether
  2. washthe organic layer washed
  3. customdried
  4. customevaporated
  5. distillationfinally subjected to a fractional distillation

출처 및 근거

ORD 기록
ord-aac398c990874d629dd797e75c4f54eb
출처 데이터셋
uspto-grants-1978_09
특허 번호
US04114630

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