Dimethylamine → 4-Dimethylamino-1,3-dimethyl-6-phenyl-1H-pyrazolo[3,4-b]pyridine

HRID 1764096노트

반응식

HRID 1764096 반응식
Cl[C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:5]=[C:4]2[N:14]([CH3:18])[N:15]=[C:16]([CH3:17])[C:3]=12.[CH3:19][NH:20][CH3:21]>>[CH3:19][N:20]([CH3:21])[C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:5]=[C:4]2[N:14]([CH3:18])[N:15]=[C:16]([CH3:17])[C:3]=12

참가 물질

3

반응물 2

HCID 674DimethylamineHCID 227705064-chloro-1,3-dimethyl-6-phenyl-1H-pyrazolo[3,4-b]pyridine

생성물 1

HCID 227704984-Dimethylamino-1,3-dimethyl-6-phenyl-1H-pyrazolo[3,4-b]pyridine

실험 절차

15.5 gms. of 4-chloro-1,3-dimethyl-6-phenyl-1H-pyrazolo[3,4-b]pyridine (0.06 mol.) are added to 132 ml. of a solution of dimethylamine (40%). The reaction mixture is heated at 190°-200° C. for 16 hours in an autoclave and after cooling to room temperature is evaporated in vacuo. The residue is treated with water and extracted with ether. After evaporation of the extract, the 4-dimethylamino-1,3-dimethyl-6-phenyl-1H-pyrazolo[3,4-b]pyridine (15.6 gms. = 98%) is recrystallized from ligroin, m.p. 90°-91° C.

후처리

  1. temperatureThe reaction mixture is heated at 190°-200° C. for 16 hours in an autoclave
  2. customis evaporated in vacuo
  3. additionThe residue is treated with water
  4. extractionextracted with ether
  5. customAfter evaporation of the extract
  6. customthe 4-dimethylamino-1,3-dimethyl-6-phenyl-1H-pyrazolo[3,4-b]pyridine (15.6 gms. = 98%) is recrystallized from ligroin, m.p. 90°-91° C.

출처 및 근거

ORD 기록
ord-4264836c56804627b9e7643e4485dd31
출처 데이터셋
uspto-grants-1978_09
특허 번호
US04115394

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