p-(1-Cyclooctenyl)-anisol → p-(1-Cyclooctenyl)-phenol

HRID 1764129

반응식

HRID 1764129 반응식
[C:1]1([C:9]2[CH:14]=[CH:13][C:12]([O:15]C)=[CH:11][CH:10]=2)[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH:2]=1.Cl.N1C=CC=CC=1>O>[C:1]1([C:9]2[CH:10]=[CH:11][C:12]([OH:15])=[CH:13][CH:14]=2)[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH:2]=1

참가 물질

4

반응물 2

HCID 284297p-(1-Cyclooctenyl)-anisolHCID 10176127Pyridinium chloride

생성물 1

HCID 53964233p-(1-Cyclooctenyl)-phenol

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
180 °C

실험 절차

80 Grams of p-(1-cyclooctenyl)-anisol and 175 g of pyridine-hydrochloride are thoroughly mixed and heated for 4 hours under nitrogen to 180° C. The mixture is cooled, treated with water and extracted with benzene. The benzene extracts are shaken with 3×100 ml of N-sodium hydroxide solution. The alkaline phase is acidified with 2N hydrochloric acid and extracted with ether. The ether solution is dried over sodium sulphate and evaporated. The residue is recrystallised from benzene-petroleum ether to yield the p-(1-cyclooctenyl)-phenol (m.p. 95°-97° C).

후처리

  1. temperatureThe mixture is cooled
  2. extractionextracted with benzene
  3. extractionextracted with ether
  4. dry with materialThe ether solution is dried over sodium sulphate
  5. customevaporated
  6. customThe residue is recrystallised from benzene-petroleum ether

출처 및 근거

ORD 기록
ord-f746f2763f964198a8ba9a3117101512
출처 데이터셋
uspto-grants-1978_09
특허 번호
US04115416

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