O-Phenylenediamine → 4-(2-Aminoanilino)-2,5-dihydrothiophene-3-carbonitrile

HRID 1764251노트

반응식

HRID 1764251 반응식
O=[C:2]1[CH:6]([C:7]#[N:8])[CH2:5][S:4][CH2:3]1.[C:9]1([NH2:16])[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[NH2:15]>C(O)(=O)C>[NH2:15][C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=1[NH:16][C:2]1[CH2:3][S:4][CH2:5][C:6]=1[C:7]#[N:8]

참가 물질

4

반응물 2

HCID 7243O-PhenylenediamineHCID 3266764-Oxothiolane-3-carbonitrile

생성물 1

HCID 203877024-(2-Aminoanilino)-2,5-dihydrothiophene-3-carbonitrile

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

3-Keto-4-cyanotetrahydrothiophene (80 g, 0.629 mol) and o-phenylenediamine (68 g, 0.629 mol) were dissolved by heating in 1.5 litres of industrial methylated spirit. To the solution, glacial acetic acid (3 ml) was added, the solution then being heated under reflux with mechanical stirring for 24 hours. The solution was then chilled and filtered to give the title product as a solid, m.p. 163° C.

후처리

  1. temperaturethe solution then being heated
  2. temperatureunder reflux
  3. temperatureThe solution was then chilled
  4. filtrationfiltered

출처 및 근거

ORD 기록
ord-b47d6d96eb4c4ecca3572f4ea27dd5df
출처 데이터셋
uspto-grants-1978_09
특허 번호
US04115568

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