2-Methylbenzenesulfonic acid → HCID 22768128, 화합물

HRID 1764414노트

반응식

HRID 1764414 반응식
[CH:1]([N:4]([CH2:9][CH:10]([O:14][CH2:15][CH3:16])[O:11][CH2:12]C)[C:5](=[O:8])[CH2:6][Cl:7])([CH3:3])[CH3:2].C1(C)C(S(O)(=O)=O)=CC=CC=1.C(=O)([O-])[O-].[Na+].[Na+]>C(O)C>[CH:1]([N:4]([CH2:9][CH:10]1[O:11][CH2:12][CH2:16][CH2:15][O:14]1)[C:5](=[O:8])[CH2:6][Cl:7])([CH3:2])[CH3:3]

참가 물질

5

반응물 3

HCID 69252-Methylbenzenesulfonic acidHCID 10340Sodium CarbonateHCID 22768137HCID 22768137, 화합물

생성물 1

HCID 22768128HCID 22768128, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

N-Isopropyl-N-(2,2-diethoxyethyl)-α-chloroacetamide (10 grams), propandiol-1,3 (2.9 ml) and trace amounts of toluenesulfonic acid were charged into a glass reaction vessel equipped with a mechanical stirrer, thermometer and reflux condenser. The reaction mixture was heated until no more ethanol was given off. After this time sodium carbonate (1 gram) was added to the mixture with stirring and the resulting mixture was distilled to yield the desired product N-isopropyl-N-(1,3-dioxan-2-ylmethyl)-α-chloroacetamide having a boiling point of 165° C. at 1.0 mm of Hg pressure.

후처리

  1. additionwere charged into a glass reaction vessel
  2. customequipped with a mechanical stirrer
  3. temperaturethermometer and reflux condenser
  4. distillationthe resulting mixture was distilled

출처 및 근거

ORD 기록
ord-e184700f00514eccb8cf6574043b081f
출처 데이터셋
uspto-grants-1978_09
특허 번호
US04116670

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