Chloroacetanilide → N-phenyl-2-(1,1,3-trioxo-1,2-benzothiazol-2-yl)acetamide

HRID 1764452

반응식

HRID 1764452 반응식
[S:1]1([C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:5](=[O:6])[NH:4]1)(=[O:3])=[O:2].[Na].Cl[CH2:15][C:16]([NH:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[O:17]>CN(C)C=O>[C:19]1([NH:18][C:16]([CH2:15][N:4]2[C:5](=[O:6])[C:7]3[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=3)[S:1]2(=[O:2])=[O:3])=[O:17])[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

참가 물질

4

반응물 2

HCID 11485ChloroacetanilideHCID 24181110Benzosulfinide sodium; Garantose sodium

생성물 1

HCID 677934N-phenyl-2-(1,1,3-trioxo-1,2-benzothiazol-2-yl)acetamide수율 62.9%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A solution of 22.6g (0.11 mole) of sodium saccharin and 16.7g (0.1 mole) of N-chloroacetylaniline in 150ml of dimethylformamide is heated on a steam bath for one hour, allowed to stir at room temperature for 16 hrs. and poured into ice-water. The resulting precipitate is collected and dissolved in dichloromethane. This solution is dried over magnesium sulfate, and the solvent is evaporated. The residue is recrystallized from methanol to give 19.9g of product, mp. 180°-182° C. EXAMPLE 2 ##STR5##

후처리

  1. customThe resulting precipitate is collected
  2. dissolutiondissolved in dichloromethane
  3. dry with materialThis solution is dried over magnesium sulfate
  4. customthe solvent is evaporated
  5. customThe residue is recrystallized from methanol

출처 및 근거

ORD 기록
ord-57a689350faf440db8502e219738db50
출처 데이터셋
uspto-grants-1978_09
특허 번호
US04116964

연결된 노트

불러오는 중…