Benzeneacetic acid, alpha-methyl-4-(1,3,4,7-tetrahydro-1-oxo-2H-isoindol-2-yl)- → Aluminium alpha-[4-(1-oxo-4,7-dihydro-2-isoindolinyl)phenyl]propionate

HRID 1764497

반응식

HRID 1764497 반응식
[O:1]=[C:2]1[C:10]2[CH2:9][CH:8]=[CH:7][CH2:6][C:5]=2[CH2:4][N:3]1[C:11]1[CH:16]=[CH:15][C:14]([CH:17]([CH3:21])[C:18]([OH:20])=[O:19])=[CH:13][CH:12]=1.O.O.O.O.O.O.[Cl-].[Al+3:29].[Cl-].[Cl-]>O>[O:1]=[C:2]1[C:10]2[CH2:9][CH:8]=[CH:7][CH2:6][C:5]=2[CH2:4][N:3]1[C:11]1[CH:16]=[CH:15][C:14]([CH:17]([CH3:21])[C:18]([O-:20])=[O:19])=[CH:13][CH:12]=1.[Al+3:29].[O:1]=[C:2]1[C:10]2[CH2:9][CH:8]=[CH:7][CH2:6][C:5]=2[CH2:4][N:3]1[C:11]1[CH:16]=[CH:15][C:14]([CH:17]([CH3:21])[C:18]([O-:20])=[O:19])=[CH:13][CH:12]=1.[O:1]=[C:2]1[C:10]2[CH2:9][CH:8]=[CH:7][CH2:6][C:5]=2[CH2:4][N:3]1[C:11]1[CH:16]=[CH:15][C:14]([CH:17]([CH3:21])[C:18]([O-:20])=[O:19])=[CH:13][CH:12]=1

참가 물질

4

반응물 2

HCID 3047153Benzeneacetic acid, alpha-methyl-4-(1,3,4,7-tetrahydro-1-oxo-2H-isoindol-2-yl)-HCID 9794789AlCl3.6H2O

생성물 1

HCID 22768525Aluminium alpha-[4-(1-oxo-4,7-dihydro-2-isoindolinyl)phenyl]propionate수율 103%

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

A mixture of 8.37 g (0.03 mole) of α-[4-(1-oxo-4,7-dihydro-2-isoindolinyl)phenyl]propionic acid and 30 ml of water was stirred for about 1 hour. At the end of this time, a solution of 2.41 g (0.01 mole) of aluminium chloride hexahydrate in 50 ml of water was added to the resulting solution. The white precipitate which was produced was collected by filtration and washed with 75 ml of water. The resulting white solid was then dried at 105° C. for 4 hours. There were obtained 9.0 g of a white solid, sparingly soluble in most organic solvents, slightly soluble in dimethyl sulphoxide and having a melting point above 300° C.

후처리

  1. customThe white precipitate which was produced
  2. filtrationwas collected by filtration
  3. washwashed with 75 ml of water
  4. customThe resulting white solid was then dried at 105° C. for 4 hours

출처 및 근거

ORD 기록
ord-9756a47165b84f16b5895d7d98b48bcf
출처 데이터셋
uspto-grants-1978_09
특허 번호
US04116972

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