Water → 2-(2,3-dihydro-1H-inden-2-yl)ethanol

HRID 1764887

반응식

HRID 1764887 반응식
[CH2:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH:2]1[CH2:10][C:11](OCC)=[O:12].[H-].[H-].[H-].[H-].[Li+].[Al+3].O>CCOCC.CCOC(C)=O.[O-]S([O-])(=O)=O.[Mg+2]>[CH2:3]1[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[CH2:1][CH:2]1[CH2:10][CH2:11][OH:12]

참가 물질

7

반응물 3

HCID 962WaterHCID 10104359Ethyl 2-(2,3-dihydro-1H-inden-2-yl)acetateHCID 21226445Aluminium lithium hydride

생성물 1

HCID 103520002-(2,3-dihydro-1H-inden-2-yl)ethanol

시약·촉매·용매 3

HCID 3283Diethyl Ether용매HCID 8857Ethyl Acetate용매HCID 24083Sulfuric acid magnesium salt (1:1)용매

반응 조건

온도
0 °C

실험 절차

To a solution of ethyl 2,3-dihydro-1H-inden-2-ylacetate (285 mg, 1.39 mmol) in Et2O (5 mL) at 0° C. under N2 was added LAH (53 mg, 1.39 mmol). After stirring for 40 minutes at 0° C., 0.4 mL of H2O was added to quench the reaction. The reaction mixture was diluted with EtOAc (100 mL) and MgSO4 was added with stirring. The reaction mixture was then filtered and concentrated in vacuo to a clear oil. 2-(2,3-dihydro-1H-inden-2-yl)ethanol was isolated without further purification.

후처리

  1. customto quench
  2. customthe reaction
  3. additionwas added
  4. stirringwith stirring
  5. filtrationThe reaction mixture was then filtered
  6. concentrationconcentrated in vacuo to a clear oil

출처 및 근거

ORD 기록
ord-b3a625809a514b65994dfe9873c578c1
출처 데이터셋
uspto-grants-2007_06
특허 번호
USRE039679E1

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