참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 4-tert-Butylphenol | HCID 7393 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | N-butyl-5-fluoro-2-nitroaniline | HCID 59566264 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 2-n-Butylamino-4-(4-t-butylphenoxy)nitrobenzene | HCID 66977422 | — |
반응 단계
A mixture of 2-n-butylamino-4-fluoronitrobenzene (10 mmol), 4-t-butylphenol (13 mmol), solid K2CO3 (30 mmol) and DMF (30 mL) was heated with stirring at 90° C. for 10 h. The reaction was quenched by cold H2O (50 mL), and the resulting mixture was extracted with EtOAc (3×100 mL). The combined EtOAc extracts were washed with brine (2×50 mL) and dried (anhydrous Na2SO4). The solvent was removed in vacuo, and the crude products were purified by silica gel column chromatography (eluting with 10% EtOAc in hexane), giving 2-n-butylamino-4-(4-t-butylphenoxy)nitrobenzene.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07737285B2 |
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| 출처 데이터셋 | uspto-grants-2010_06 |
|---|
| ORD ID | ord-0b8aca2fd88841b99fc0aa3fcbd77d96 |
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| 출처 메모 | uspto-grants-2010_06 |
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