5-Methoxy-o-toluidine → 4-(5-Methoxy-2-methylanilino)-2-phenyl-6-(trifluoromethyl)pyrimidine

HRID 1765183

반응식

HRID 1765183 반응식
Cl[C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[N:3]=1.[CH3:18][O:19][C:20]1[CH:21]=[CH:22][C:23]([CH3:27])=[C:24]([CH:26]=1)[NH2:25]>>[CH3:18][O:19][C:20]1[CH:21]=[CH:22][C:23]([CH3:27])=[C:24]([CH:26]=1)[NH:25][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[N:3]=1

참가 물질

3

반응물 2

HCID 995005-Methoxy-o-toluidineHCID 6141014-Chloro-2-phenyl-6-(trifluoromethyl)pyrimidine

생성물 1

HCID 227324504-(5-Methoxy-2-methylanilino)-2-phenyl-6-(trifluoromethyl)pyrimidine

실험 절차

The title compound was prepared from a mixture of 4-chloro-2-phenyl-6-(trifluoromethyl)pyrimidine (50 mg, 0.193 mmol) and 5-methoxy-2-methylaniline (40 mg, 0.290 mmol) similar to Example 77 and isolated as a tan oil (33 mg, 48%). 1H NMR (CDCl3): 8.46–8.42 (m, 2H), 7.50–7.46 (m, 3H), 7.22 (d, J=8.4 Hz, 1H), 7.01 (d, J=2.4 Hz, 1H), 6.92 (s, 1H), 6.80 (dd, J=2.6, 8.6 Hz, 1H), 6.61 (s, 1H), 3.81 (s, 3H), 2.22 (s, 3H).

출처 및 근거

ORD 기록
ord-1a8e75098ab544feb4d31785984ba896
출처 데이터셋
uspto-grants-2007_06
특허 번호
US07226927B2

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