Butylamine → 2-n-Butylamino-6-(3-diethylaminopropoxy)-4-fluoronitrobenzene

HRID 17652

반응식

HRID 17652 반응식
[CH2:1]([N:3]([CH2:19][CH3:20])[CH2:4][CH2:5][CH2:6][O:7][C:8]1[C:13]([N+:14]([O-:16])=[O:15])=[C:12](F)[CH:11]=[C:10]([F:18])[CH:9]=1)[CH3:2].C(N(CC)CC)C.[CH2:28]([NH2:32])[CH2:29][CH2:30][CH3:31]>CN(C=O)C>[CH2:28]([NH:32][C:12]1[CH:11]=[C:10]([F:18])[CH:9]=[C:8]([O:7][CH2:6][CH2:5][CH2:4][N:3]([CH2:19][CH3:20])[CH2:1][CH3:2])[C:13]=1[N+:14]([O-:16])=[O:15])[CH2:29][CH2:30][CH3:31]

참가 물질

5

반응물 3

HCID 8007ButylamineHCID 8471TriethylamineHCID 669775546-(3-Diethylaminopropoxy)-2,4-difluoronitrobenzene

생성물 1

HCID 669774812-n-Butylamino-6-(3-diethylaminopropoxy)-4-fluoronitrobenzene

시약·촉매·용매 1

HCID 6228Dimethylformamide용매2회

실험 절차

To a stirred solution of 6-(3-diethylaminopropoxy)-2,4-difluoronitrobenzene (11 mmol) and triethylamine (22 mmol) in DMF (20 mL), a solution of n-butylamine (11 mmol) in DMF (8 mL) was added dropwise at rt, and the mixture was stirred at rt for 10 h. The reaction was quenched by cold H2O (50 mL), and the resulting mixture was extracted with EtOAc (3×100 mL). The combined EtOAc extracts were washed with brine (3×50 mL) and dried (anhydrous Na2SO4). The solvent was removed in vacuo to afford the desired 2-n-butylamino-6-(3-diethylaminopropoxy)-4-fluoronitrobenzene which was used for further transformation.

후처리

  1. customThe reaction was quenched by cold H2O (50 mL)
  2. extractionthe resulting mixture was extracted with EtOAc (3×100 mL)
  3. washThe combined EtOAc extracts were washed with brine (3×50 mL)
  4. dry with materialdried (anhydrous Na2SO4)
  5. customThe solvent was removed in vacuo

출처 및 근거

ORD 기록
ord-da35513542f84da8825139e72ef6d024
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07737285B2

연결된 노트

불러오는 중…