Isopropylamine → 1-{4-[2-(Allyloxy)-ethyl]phenoxy}-3-isopropylamino propan-2-ol

HRID 1765492노트

반응식

HRID 1765492 반응식
[CH2:1]([O:4][CH2:5][CH2:6][C:7]1[CH:17]=[CH:16][C:10]([O:11][CH2:12][CH:13]2[CH2:15][O:14]2)=[CH:9][CH:8]=1)[CH:2]=[CH2:3].[CH:18]([NH2:21])([CH3:20])[CH3:19]>CO>[CH2:1]([O:4][CH2:5][CH2:6][C:7]1[CH:17]=[CH:16][C:10]([O:11][CH2:12][CH:13]([OH:14])[CH2:15][NH:21][CH:18]([CH3:20])[CH3:19])=[CH:9][CH:8]=1)[CH:2]=[CH2:3]

참가 물질

4

반응물 2

HCID 6363IsopropylamineHCID 167262652-[4-(2-Allyloxy-ethyl)-phenoxymethyl]-oxirane

생성물 1

HCID 116593381-{4-[2-(Allyloxy)-ethyl]phenoxy}-3-isopropylamino propan-2-ol수율 75%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of the compound of formula (5) (3.70 g, 0.016 mol), isopropyl amine (7.46 ml, 0.127 mol) in methanol (20 ml) was stirred under reflux for 2 hours and then concentrated. The residue was partitioned between chloroform and water. The organic layer was dried over anhydrous sodium sulphate, filtered and concentrated. The residue was crystallized from pet ether to afford compound of formula (1) as a white solid 3.47 g (75%) mp 52–53° C.

후처리

  1. temperatureunder reflux for 2 hours
  2. concentrationconcentrated
  3. customThe residue was partitioned between chloroform and water
  4. dry with materialThe organic layer was dried over anhydrous sodium sulphate
  5. filtrationfiltered
  6. concentrationconcentrated
  7. customThe residue was crystallized from pet ether

출처 및 근거

ORD 기록
ord-2f976705f55d4c7eb0570c4bdabb6027
출처 데이터셋
uspto-grants-2007_06
특허 번호
US07227039B2

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