N,N-diethyl-N-[3-(3-nitrophenoxy)propyl]amine → N-[3-(3-aminophenoxy)propyl]-N,N-diethylamine

HRID 17659

반응식

HRID 17659 반응식
[CH2:1]([N:3]([CH2:17][CH3:18])[CH2:4][CH2:5][CH2:6][O:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([N+:14]([O-])=O)[CH:9]=1)[CH3:2]>CO.[Pd]>[NH2:14][C:10]1[CH:9]=[C:8]([CH:13]=[CH:12][CH:11]=1)[O:7][CH2:6][CH2:5][CH2:4][N:3]([CH2:1][CH3:2])[CH2:17][CH3:18]

참가 물질

4

반응물 1

HCID 22012884N,N-diethyl-N-[3-(3-nitrophenoxy)propyl]amine

생성물 1

HCID 28300924N-[3-(3-aminophenoxy)propyl]-N,N-diethylamine

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

The N,N-diethyl-N-[3-(3-nitrophenoxy)propyl]amine (1 mmol) was dissolved in MeOH (5 mL) and hydrogenated in the presence of 10% Pd/C (50 mg) until completion as indicated by TLC or HPLC, according to General Procedure H. The reaction mixture was then filtered to remove the catalyst. The solvent was removed in vacuuo to afford the desired N-[3-(3-aminophenoxy)propyl]-N,N-diethylamine, which was used directly for further transformation without further purification.

후처리

  1. filtrationThe reaction mixture was then filtered
  2. customto remove the catalyst
  3. customThe solvent was removed in vacuuo

출처 및 근거

ORD 기록
ord-7a0fcccdeb344ea994fe2adf34712ddf
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07737285B2

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