Methanol → (2-Fluoro-6-(trifluoromethyl)phenyl)methanamine

HRID 1766040노트

반응식

HRID 1766040 반응식
[F:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]([F:13])([F:12])[F:11])[C:3]=1[C:4]#[N:5].CO>C1COCC1>[F:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]([F:11])([F:12])[F:13])[C:3]=1[CH2:4][NH2:5]

참가 물질

4

반응물 2

HCID 887MethanolHCID 1456132-Fluoro-6-(trifluoromethyl)benzonitrile

생성물 1

HCID 2774790(2-Fluoro-6-(trifluoromethyl)phenyl)methanamine수율 100%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

To 2-fluoro-6-(trifluoromethyl)benzonitrile (45 g, 0.238 mmol) in 60 mL of THF was added 1 M BH3:THF slowly at 60° C. and the resulting solution was refluxed overnight. The reaction mixture was cooled to ambient temperature. Methanol (420 mL) was added slowly and stirred well. The solvents were then evaporated and the residue was partitioned between EtOAc and water. The organic layer was dried over Na2SO4. Evaporation gave 4a as a yellow oil (46 g, 0.238 mmol). MS (CI) m/z 194.0 (MH+).

후처리

  1. customThe solvents were then evaporated
  2. customthe residue was partitioned between EtOAc and water
  3. dry with materialThe organic layer was dried over Na2SO4
  4. customEvaporation

출처 및 근거

ORD 기록
ord-20ec6489a4d34c448c222a1783429dfb
출처 데이터셋
uspto-grants-2007_06
특허 번호
US07229995B2

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