Benzyl chloroformate → HCID 69289120, 화합물

HRID 1766062노트

반응식

HRID 1766062 반응식
[C:1]([NH:5][C:6]([C:8]1[S:25][C:11]2[N:12]=[C:13]([S:23][CH3:24])[N:14]=[C:15]([C:16]3[CH:21]=[CH:20][CH:19]=[C:18]([OH:22])[CH:17]=3)[C:10]=2[C:9]=1[NH2:26])=[O:7])([CH3:4])([CH3:3])[CH3:2].Cl[C:28]([O:30][CH2:31][C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)=[O:29]>>[C:1]([NH:5][C:6]([C:8]1[S:25][C:11]2[N:12]=[C:13]([S:23][CH3:24])[N:14]=[C:15]([C:16]3[CH:21]=[CH:20][CH:19]=[C:18]([O:22][C:28]([O:30][CH2:31][C:32]4[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=4)=[O:29])[CH:17]=3)[C:10]=2[C:9]=1[NH2:26])=[O:7])([CH3:4])([CH3:2])[CH3:3]

참가 물질

3

반응물 2

HCID 10387Benzyl chloroformateHCID 11531195HCID 11531195, 화합물

생성물 1

HCID 69289120HCID 69289120, 화합물

실험 절차

The reaction of tert-butyl 5-amino-2-methylthio-4-(3-hydroxyphenyl)-thieno[2,3-d]pyrimidine-6-carboxamide (example 1f, 100 mg) with benzyl chloroformate (368 μl) was performed according to the methods described in example 1g. The title compound was purified by HPLC using a Luna C-18 column with the following gradient: CH3CN/H2O=10/90 to 90/10 (v/v) in 30 min. The title compound was then lyophilized from a mixture of 1,4-dioxane and H2O.

후처리

  1. customThe title compound was purified by HPLC
  2. additionThe title compound was then lyophilized from a mixture of 1,4-dioxane and H2O

출처 및 근거

ORD 기록
ord-fa622324ce764d1682faf2129e5e857c
출처 데이터셋
uspto-grants-2007_06
특허 번호
US07229990B2

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