4-Nitrophenyl chloroformate → HCID 69328481, 화합물

HRID 1766065노트

반응식

HRID 1766065 반응식
[C:1]([NH:5][C:6]([C:8]1[S:25][C:11]2[N:12]=[C:13]([S:23][CH3:24])[N:14]=[C:15]([C:16]3[CH:21]=[CH:20][CH:19]=[C:18]([OH:22])[CH:17]=3)[C:10]=2[C:9]=1[NH2:26])=[O:7])([CH3:4])([CH3:3])[CH3:2].Cl[C:28]([O:30][C:31]1[CH:36]=[CH:35][C:34]([N+:37]([O-:39])=[O:38])=[CH:33][CH:32]=1)=[O:29]>>[C:1]([NH:5][C:6]([C:8]1[S:25][C:11]2[N:12]=[C:13]([S:23][CH3:24])[N:14]=[C:15]([C:16]3[CH:21]=[CH:20][CH:19]=[C:18]([O:22][C:28]([O:30][C:31]4[CH:32]=[CH:33][C:34]([N+:37]([O-:39])=[O:38])=[CH:35][CH:36]=4)=[O:29])[CH:17]=3)[C:10]=2[C:9]=1[NH2:26])=[O:7])([CH3:4])([CH3:2])[CH3:3]

참가 물질

3

반응물 2

HCID 821294-Nitrophenyl chloroformateHCID 11531195HCID 11531195, 화합물

생성물 1

HCID 69328481HCID 69328481, 화합물

실험 절차

The reaction of tert-butyl 5-amino-2-methylthio-4-(3-hydroxyphenyl)-thieno[2,3-d]pyrimidine-6-carboxamide (example 1f, 400 mg) with p-nitro-phenyl chloroformate (207 mg) was performed according to the methods described in example 1g. Evaporation of the solvent under reduced pressure yielded the crude title compound.

후처리

  1. customEvaporation of the solvent under reduced pressure

출처 및 근거

ORD 기록
ord-6a11cb1e052b4cc3b939d63ceef350e7
출처 데이터셋
uspto-grants-2007_06
특허 번호
US07229990B2

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