홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Ethanol → HCID 86614568, 화합물

HRID 1766089
노트
인쇄 미리보기

반응식

HRID 1766089 반응식
C(=O)([O-])[O-].[K+].[K+].[CH2:7]([CH:9]([C:17]([O-:19])=[O:18])[C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[CH3:8].[C:20]([C:22]1[C:23]([C:32]2[CH:37]=[CH:36][CH:35]=[C:34]([N+:38]([O-:40])=[O:39])[CH:33]=2)=[N:24][C:25]([S:30][CH3:31])=[N:26][C:27]=1C=C)#[N:21].[CH3:41][CH2:42]O>C1(C)C=CC=CC=1.C(Cl)Cl.CCOC(C)=O>[C:20]([C:22]1[C:23]([C:32]2[CH:37]=[CH:36][CH:35]=[C:34]([N+:38]([O-:40])=[O:39])[CH:33]=2)=[N:24][C:25]([S:30][CH3:31])=[N:26][C:27]=1[CH2:8][CH2:7][CH:9]([C:17]([O:19][CH2:41][CH3:42])=[O:18])[C:10]([O:12][C:13]([CH3:15])([CH3:14])[CH3:16])=[O:11])#[N:21]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 4

HCID 702EthanolHCID 11430Potassium CarbonateHCID 21109084HCID 21109084, 화합물HCID 85608643HCID 85608643, 화합물

생성물 1

HCID 86614568HCID 86614568, 화합물

시약·촉매·용매 2

HCID 8857Ethyl Acetate용매
HCID 21877217
Toluene methylene chloride
용매

실험 절차

Potassium carbonate (1.88 g) and tert-butyl ethylmalonate were suspended in EtOH (82 ml) and a solution of 5-cyano-2-methylthio-4-(3-nitro-phenyl)-6-vinylpyrimidine (example 27b, 2.71 g) in toluene/CH2Cl2 (33 ml) was slowly added (ca 1.5 h). After the addition was complete, the mixture was stirred for an additional 40 min. The mixture was diluted with EtOAc and washed with water (2×) and brine. The organic layer was dried (MgSO4) and concentrated under reduced pressure. The title compound was purified by chromatography on silica gel with hept/CH2Cl2=1/1 (v/v) as eluent.

후처리

  1. additionAfter the addition
  2. washwashed with water (2×) and brine
  3. dry with materialThe organic layer was dried (MgSO4)
  4. concentrationconcentrated under reduced pressure
  5. customThe title compound was purified by chromatography on silica gel with hept/CH2Cl2=1/1 (v/v) as eluent

출처 및 근거

ORD 기록
ord-9bf84ca3af0c4590b086e1e7c126b7e8
출처 데이터셋
uspto-grants-2007_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07229990B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트