Oxalyl chloride → HCID 21110068, 화합물

HRID 1766152노트

반응식

HRID 1766152 반응식
[C:1](Cl)(=O)[C:2]([Cl:4])=[O:3].[C:7]1([N:17]2[C:21]3=[N:22][CH:23]=[CH:24][CH:25]=[C:20]3C(C(O)=O)=[CH:18]2)[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH:10]=[CH:9][N:8]=1>ClCCl>[ClH:4].[Cl:4][C:2]([C:1]1[C:20]2[C:21](=[N:22][CH:23]=[CH:24][CH:25]=2)[N:17]([C:7]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[CH:10]=[CH:9][N:8]=2)[CH:18]=1)=[O:3]

참가 물질

4

반응물 2

HCID 65578Oxalyl chlorideHCID 211100551-(isoquinolin-1-yl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid

생성물 1

HCID 21110068HCID 21110068, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
20 °C

실험 절차

0.61 cm3 (6.91 mmol) of oxalyl chloride was added, at a temperature in the region of 20° C., to 1.0 g (3.46 mmol) of 1-(isoquinolin-1-yl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid in suspension in 30 cm3 of dichloromethane. After stirring at a temperature in the region of 20° C. for 2 h, the reaction mixture was concentrated to dryness under reduced pressure (2.7 kPa) and used directly in the following stage.

후처리

  1. concentrationthe reaction mixture was concentrated to dryness under reduced pressure (2.7 kPa)

출처 및 근거

ORD 기록
ord-f4e84914bb324b0297ad8789583398df
출처 데이터셋
uspto-grants-2007_06
특허 번호
US07230007B2

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