1-(Diphenylmethyl)-3-[(2-nitrophenylmethyl)amino]-azetidine → 3-[(2-Aminophenylmethyl)amino]-1-(diphenylmethyl)-azetidine

HRID 1766182노트

반응식

HRID 1766182 반응식
[C:1]1([CH:7]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[N:8]2[CH2:11][CH:10]([NH:12][CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[N+:20]([O-])=O)[CH2:9]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>CO.[Rh].C>[NH2:20][C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=1[CH2:13][NH:12][CH:10]1[CH2:9][N:8]([CH:7]([C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=2)[C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[CH2:11]1

참가 물질

4

반응물 1

HCID 211099031-(Diphenylmethyl)-3-[(2-nitrophenylmethyl)amino]-azetidine

생성물 1

HCID 211099093-[(2-Aminophenylmethyl)amino]-1-(diphenylmethyl)-azetidine

시약·촉매·용매 2

HCID 10080373Rhodium carbon촉매HCID 887Methanol용매

실험 절차

A solution of 20.0 g (0.5355 mol) of 1-(diphenylmethyl)-3-[(2-nitrophenylmethyl)amino]-azetidine in 200 ml of methanol was hydrogenated in the presence of 4 g of 5% rhodium/charcoal for 5 hours at ambient temperature. The catalyst was filtered off, the filtrate was concentrated by evaporation in vacuo. 17.7 g (96% of theoretical) of a colourless, highly viscous oil were obtained, which was further processed without any additional purification.

후처리

  1. filtrationThe catalyst was filtered off
  2. concentrationthe filtrate was concentrated by evaporation in vacuo
  3. custom17.7 g (96% of theoretical) of a colourless, highly viscous oil were obtained
  4. customwhich was further processed without any additional purification

출처 및 근거

ORD 기록
ord-734891da2bc948f3b1ba69c827e3506a
출처 데이터셋
uspto-grants-2007_06
특허 번호
US07230001B1

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