Triethylamine → N-(4-benzoylphenyl)-4-biphenylcarboxamide

HRID 1766318

반응식

HRID 1766318 반응식
[NH2:1][C:2]1[CH:15]=[CH:14][C:5]([C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[O:7])=[CH:4][CH:3]=1.[C:16]1([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[CH:21]=[CH:20][C:19]([C:22](Cl)=[O:23])=[CH:18][CH:17]=1.C(N(CC)CC)C>C1COCC1>[C:6]([C:5]1[CH:4]=[CH:3][C:2]([NH:1][C:22]([C:19]2[CH:20]=[CH:21][C:16]([C:25]3[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=3)=[CH:17][CH:18]=2)=[O:23])=[CH:15][CH:14]=1)(=[O:7])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 143464-AminobenzophenoneHCID 841514-Phenylbenzoyl chloride

생성물 1

HCID 1590830N-(4-benzoylphenyl)-4-biphenylcarboxamide수율 63.5%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Reaction of 4-aminobenzophenone (102 mg, 0.52 mmol) in THF (6 mL) with 4-biphenylcarbonyl chloride (143 mg, 0.65 mmol) in presence of triethylamine (90 μL, 0.65 mmol) according to method A gave biphenyl-4-carboxylic acid (4-benzoyl-phenyl)-amide (125 mg, 0.33 mmol, 63% yield) as a yellow powder after purification by crystallisation in DCM/EtOAc.

출처 및 근거

ORD 기록
ord-de9d22677a394f28b24e1e29749a0c8c
출처 데이터셋
uspto-grants-2007_06
특허 번호
US07230020B2

연결된 노트

불러오는 중…