Methanol → 4(1H)-Quinazolinone

HRID 1767149노트

반응식

HRID 1767149 반응식
[C:1]([O-:10])(=O)[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[NH2:4].[NH4+:11].C([O-])([O-])OC.[CH3:17]O>>[N:4]1[C:3]2[C:2](=[CH:8][CH:7]=[CH:6][CH:5]=2)[C:1](=[O:10])[NH:11][CH:17]=1

참가 물질

4

반응물 3

HCID 887MethanolHCID 53629101MethylorthoformateHCID 6736264670346-37-1

생성물 1

HCID 1354087534(1H)-Quinazolinone수율 81%

실험 절차

In a 2-mL volume stainless steel pressure-resistant vessel were placed 280 mg (1.8 mmol) of ammonium anthranilate (prepared in the same manner as in Reference Example 1), 400 mg (3.6 mmol) of methyl orthoformate, and 1.5 mL of methanol. The reaction was carried out at 120° C. for 2 hours. After the reaction was complete, the reaction mixture was cooled to room temperature and analyzed (according to absolute quantitative analysis) by high performance liquid chromatography. There was produced 214 mg (reaction yield: 81%) of quinazolin-4-one.

후처리

  1. customIn a 2-mL volume stainless steel pressure-resistant vessel were placed

출처 및 근거

ORD 기록
ord-b2e795dc31064a299c1d4592b82795e1
출처 데이터셋
uspto-grants-2007_06
특허 번호
US07232903B2

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