Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Pyrazinecarboxylic acid → Pyrazine-2-carboxylic acid 4-(4-amino-2-methyl-quinolin-6-ylcarbamoyl)-benzylamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Pyrazinecarboxylic acid | HCID 1047 | — |
| 반응물 | Ethylmorpholine | HCID 7525 | — |
| 반응물 | O-[(Ethoxycarbonyl)cyanomethylenamino]-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733286 | — |
| 반응물 | 4-Aminomethyl-N-(4-amino-2-methyl-quinolin-6-yl)-benzamide | HCID 17864623 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | Pyrazine-2-carboxylic acid 4-(4-amino-2-methyl-quinolin-6-ylcarbamoyl)-benzylamide | HCID 12110091 | 111.2% |
반응 단계
To a solution of 10.5 mg (0.08 mmol) of 2-pyrazinecarboxylic acid in 1 ml of DMF were added 27.9 mg (0.085 mmol) TOTU. After 15 min at room temperature 55 mg (0.085 mmol) of 4-Aminomethyl-N-(4-amino-2-methyl-quinolin-6-yl)-benzamide and 39 mg (0.34 mmol) of N-ethylmorpholine were added. After 24 h stirring at room temperature the solution was evaporated and the residue was treated with acetonitrile and water containing 0.005% trifluoroacetic acid. The precipitate was filtered to give 36.7 mg (71%) of the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07235558B2 |
| 출처 데이터셋 | uspto-grants-2007_06 |
| ORD ID | ord-4c793ec7f4c44b5887cadf00bac54487 |
| 출처 메모 | uspto-grants-2007_06 |