Ethyl 4-methyl-2-[3-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxylate → {4-Methyl-2-[3-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methanol

반응식

C([O:3][C:4]([C:6]1[S:10][C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([C:17]([F:20])([F:19])[F:18])[CH:12]=2)=[N:8][C:7]=1[CH3:21])=O)C.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[CH3:21][C:7]1[N:8]=[C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([C:17]([F:20])([F:18])[F:19])[CH:12]=2)[S:10][C:6]=1[CH2:4][OH:3]

참가 물질

반응물 2

HCID 2774390Ethyl 4-methyl-2-[3-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxylate

HCID 21226445Aluminium lithium hydride

생성물 1

HCID 22647518{4-Methyl-2-[3-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methanol

실험 절차

In analogy to the procedure described in example 8 c], 4-methyl-2-(3-trifluoromethyl-phenyl)-thiazole-5-carboxylic acid ethyl ester was reduced with lithium aluminum hydride to give [4-methyl-2-(3-trifluoromethyl-phenyl)-thiazol-5-yl]-methanol as colorless liquid.

출처 및 근거

ORD 기록: ord-fe4cc7b7c0a547acb746ec7d8aa15dbe
출처 데이터셋: uspto-grants-2007_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07235572B2

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