Toluene → Ethyl(6-methoxy-1-benzofuran-3-yl)acetate

HRID 1767994노트

반응식

HRID 1767994 반응식
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:6]2[C:7](=O)[CH2:8][O:9][C:5]=2[CH:4]=1.[C:13]([CH:16]=P(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)([OH:15])=[O:14].[C:36]1(C)C=CC=C[CH:37]=1>>[CH2:36]([O:15][C:13](=[O:14])[CH2:16][C:7]1[C:6]2[CH:11]=[CH:12][C:3]([O:2][CH3:1])=[CH:4][C:5]=2[O:9][CH:8]=1)[CH3:37]

참가 물질

4

반응물 3

HCID 1140TolueneHCID 5853686-Methoxy-2,3-dihydro-1-benzofuran-3-oneHCID 10870911Carboxymethylene triphenylphosphorane

생성물 1

HCID 23614459Ethyl(6-methoxy-1-benzofuran-3-yl)acetate

실험 절차

A mixture of 6-methoxy-benzofuran-3 (2H)-one (1.64 g, 10 mmol) and (carboxymethylene)triphenylphosphorane (5.22 g, 15 mmol) was refluxed in toluene (100 ml) for 48 hrs. At the end, reaction mixture was concentrated and loaded over silica-gel column. The column was eluted with hexane (500 ml) and later with 25% ethyl acetate. The product, ethyl(6-methoxy-1-benzofuran-3-yl)acetate was obtained as a white oil. Yield: 1.8 g (76%); 235 (M+H).

후처리

  1. customAt the end, reaction mixture
  2. concentrationwas concentrated
  3. washThe column was eluted with hexane (500 ml) and later with 25% ethyl acetate

출처 및 근거

ORD 기록
ord-87cef1e8b92145739bb1c4a0394fd1b5
출처 데이터셋
uspto-grants-2007_06
특허 번호
US07235569B2

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