Toluene → Ethyl(7-methoxy-1-benzofuran-3-yl)acetate

HRID 1768004

반응식

HRID 1768004 반응식
[CH3:1][O:2][C:3]1[C:11]2[O:10][CH2:9][C:8](=O)[C:7]=2[CH:6]=[CH:5][CH:4]=1.[C:13]([CH:16]=P(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)([OH:15])=[O:14].[C:36]1(C)C=CC=C[CH:37]=1>>[CH2:36]([O:15][C:13](=[O:14])[CH2:16][C:8]1[C:7]2[CH:6]=[CH:5][CH:4]=[C:3]([O:2][CH3:1])[C:11]=2[O:10][CH:9]=1)[CH3:37]

참가 물질

4

반응물 3

HCID 1140TolueneHCID 28181127-Methoxybenzofuran-3(2H)-oneHCID 10870911Carboxymethylene triphenylphosphorane

생성물 1

HCID 22734085Ethyl(7-methoxy-1-benzofuran-3-yl)acetate

실험 절차

A mixture of 7-methoxy-benzofuran-3 (2H)-one (1.64 g, 10 mmol) and (carboxymethylene)triphenylphosphorane (5.22 g, 15 mmol) was refluxed in toluene (100 ml) for 48 hrs. At the end, the reaction mixture was concentrated and loaded over silica-gel column. The column was eluted with hexane (500 ml) and later with 25% ethyl acetate. The product, ethyl(7-methoxy-1-benzofuran-3-yl)acetate was obtained as a white oil. Yield: 1.9 g (81%); 235 (M+H).

후처리

  1. concentrationAt the end, the reaction mixture was concentrated
  2. washThe column was eluted with hexane (500 ml) and later with 25% ethyl acetate

출처 및 근거

ORD 기록
ord-271ad550a4094ff1868339aa7e1105cd
출처 데이터셋
uspto-grants-2007_06
특허 번호
US07235569B2

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