Ammonia → 4-(Imidazo[1,2-a]pyridin-3-yl)piperidin-4-ol

HRID 1768032노트

반응식

HRID 1768032 반응식
C(OC([N:8]1[CH2:13][CH2:12][C:11]([OH:23])([C:14]2[N:18]3[CH:19]=[CH:20][CH:21]=[CH:22][C:17]3=[N:16][CH:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.N>C(Cl)Cl>[N:16]1[CH:15]=[C:14]([C:11]2([OH:23])[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)[N:18]2[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=12

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 69456650HCID 69456650, 화합물

생성물 1

HCID 236144534-(Imidazo[1,2-a]pyridin-3-yl)piperidin-4-ol

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a stirred solution of 4-hydroxy-4-imidazo[1,2-a]pyridin-3-yl-piperidine-1-carboxylic acid tert-butyl ester (2.0 g 6.26 mmol) in CH2Cl2 (100 ml) trifluoro acetic acid (10 ml) was added at room temperature. The reaction mixture was stirred at room temperature for 24 hrs. At the end, the reaction mixture was basified with methanolic ammonia and concentrated to dryness. The residue was directly chromatographed over silica-gel column and eluted with methanol:10% methanolic ammonia. The product, 4-imidazo[1,2-a]pyridin-3-yl-piperidin-4-ol was obtained as yellow oil; Yield; 620 mg (48%); 218 (M+H).

후처리

  1. concentrationconcentrated to dryness
  2. customThe residue was directly chromatographed over silica-gel column
  3. washeluted with methanol

출처 및 근거

ORD 기록
ord-3a5b1d94642e402d8a067c1d4b7dd0fe
출처 데이터셋
uspto-grants-2007_06
특허 번호
US07235569B2

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